Chickens coccidiosis is a parasitic disease with great economic significance. Coc-cidia vaccines and anticoccidial drugs are commonly used to control Eimeria infection. The present study was conducted to compare the relative effectiveness of Amprolium, Diclazuril, and Anticoccidial vaccine (COCCIVAC-D) for the prevention and control of cecal coccidiosis in broiler chickens. The clinical signs, production indices, mortal-ity %, oocyst per gram counts, gross, and histopathological lesions were parameters for the evaluation of the efficacy level for the prevention of coccidiosis. Results proved that the overall bodyweight of the vaccinated group was significantly (P<0.01) higher than the other experimental group, while the Diclazuril group showed significantly (P<0.01) lower body weight values. The histopathological lesions of the vaccinated group showed milder lesions when compared with the Amprolium and Diclazuril group, and some cases of the vaccinated group displayed the normal histological struc-ture of the intestinal tissues and glands. The severity of the lesions reflected on the OPGC along the experimental days, that the OPGC of the diclazuril group was signif-icantly higher (P<0.01) than the Amprolium and the Vaccinated group. Amprolium and Diclazuril groups had a continuous increment in the OPGC by time up to the end of the experiment, while the vaccinated group showed a continuous decrement in the OPGC by time. Based on the previous results we can conclude that vaccination has a positive impact on the prevention and control of cecal coccidiosis, which represented in the maintaining of a good bird flock performance similar to, if not better than, that obtained with conventional anticoccidial medication.