Acetaminophen-Induced Hepatotoxicity in the Last 5 Years, an Update


The global consumption of acetaminophen (APP) for pain relief and pyrexia dates back to 1883 Britain; to date, the drug is widely available over-the-counter and is marked by the WHO as an essential medicine worldwide. Overdose and APP- associated hepatotoxicity has been documented since the late 1900s, it is a global problem that continues to affect millions. The purpose of this paper is to draw attention to the mechanistic pathways of APP in terms of, toxicity in the liver, biomarkers associated with APP-induced hepatotoxicity, and potential solutions to the hepatotoxicity crisis from a comparative standpoint over the past 5 years, from 2015 to 2020.