Controlling of cadmium hazards on kidney and testis in male albino rats using bone marrow cells

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Naglaa El-Shahat Mohamed

Abstract

Twenty four male albino rats were divided equally into three groups; the first group was the control one which was treated with distilled water for 14 days, the second group was administered cadmium chloride (CdCl2) with oral dose of 22 mg/kg/b.wt./day for 14 days by gavage using a stomach tube and the third group was injected intraperitoneally 14 days post-cadmium chloride with a dose of 75x106±5 bone marrow cells (BMC) then examined after 7 days. The results showed that administration of CdCl2 to rats induced significant increase in thiobarbituric acid reactive substances (TBARS), urea, creatinine, alkaline phosphatase (ALP) and acid phosphatase (ACP) while catalase (CAT), glutathione (GSH) and testosterone levels were significantly decreased. The histological examination of renal and testicular tissues revealed that CdCl2 treated rats showed some degenerative cells in these tissues while treatment with BMC minimized such damages i.e. improvement in biochemical and histological changes were observed in CdCl2 rats treated with BMC. In conclusion, treatment of male rats with bone marrow cells can ameliorate the hazardous effects induced by CdCl2 and manifested by biochemical and histological changes.

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How to Cite
MOHAMED, Naglaa El-Shahat. Controlling of cadmium hazards on kidney and testis in male albino rats using bone marrow cells. Journal of Experimental and Applied Animal Sciences, [S.l.], v. 2, n. 2, p. 126-136, mar. 2017. ISSN 2314-5692. Available at: <http://m-sciences.com/index.php?journal=jeaas&page=article&op=view&path%5B%5D=1253>. Date accessed: 20 aug. 2017. doi: https://doi.org/10.20454/jeaas.2017.1253.
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Original Articles