Evaluation of anticonvulsant potential of aqueous methanolic extract and various fractions of Ajuga bracteosa wall

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Sumera Qasim Ambreen Malik Uttra Umme Habiba Hasan Amna Batool

Abstract

We aim to assess the anticonvulsant potential of Ajuga bracteosa Wall. The aqueous methanol extract (30:70) of Ajuga bracteosa and its n-hexane, chloroform and ethyl acetate fractions were prepared. Anticonvulsant effect was evaluated using different animal models of epilepsy. Crude extract along with its fractions at 500 and 1000 mg/kg doses, administered orally to albino mice were appraised against pentylenetetrazole-induced, strychnine-induced and picrotoxin-induced convulsions. Moreover, effect of test substances on brain GABA level and phenobarbitone induced hypnosis was also studied at dose level of 350 and 400 mg/kg. The plant extract and its fractions produced potent dose dependent anticonvulsant activity in all models of epilepsy. In addition, plant extract and fractions increased brain GABA level and potentiated phenobarbitone-induced sleep duration. From the results it can be deduced that Ajuga bracteosa possess potent anticonvulsant activity, supporting its folkloric use in the treatment of epilepsy.

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How to Cite
QASIM, Sumera et al. Evaluation of anticonvulsant potential of aqueous methanolic extract and various fractions of Ajuga bracteosa wall. Journal of Experimental and Applied Animal Sciences, [S.l.], v. 2, n. 2, p. 137-146, mar. 2017. ISSN 2314-5692. Available at: <http://m-sciences.com/index.php?journal=jeaas&page=article&op=view&path%5B%5D=1254>. Date accessed: 20 aug. 2017. doi: https://doi.org/10.20454/jeaas.2017.1254.
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