Antiasthma activity of Eucalyptus grandis essential oil and its main constituent: Vasorelaxant effect on aortic smooth muscle isolated from nomotensive rats
Oluwagbemiga S. Soyingbe
University of South Africa
Tshepiso Jan Makhafola
Bongiwe P. Mahlobo
Hussein M. Salahdeen
Oladipupo A. Lawal
Andy R. Opoku
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How to Cite

Soyingbe, O., Makhafola, T., Mahlobo, B., Salahdeen, H., Lawal, O., & Opoku, A. (2017). Antiasthma activity of Eucalyptus grandis essential oil and its main constituent: Vasorelaxant effect on aortic smooth muscle isolated from nomotensive rats. Journal of Experimental and Applied Animal Sciences, 2(2), 211-222. https://doi.org/10.20454/jeaas.2017.1287
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Abstract

Asthma is a chronic inflammatory disorder of the airways. It is characterized by an inflammation of the airways causing dysfunction. Asthma is associated with widespread airflow obstruction and increase in airway responsiveness to a variety of stimuli. An asthma attack is accompanied by wheezing, shortness of breath, chest tightness and coughing. The anti-asthmatic and anti-cough activities of the essential oils and 1,8-cineole on rats were assessed. These activities were induced and challenged with histamine and acetylcholine using an ultrasonic nebulizer for asthma and exposure to ammonia for coughs. Anti-inflammatory activities of the essential oils and 1,8-cineole were determined using the cotton pellet granuloma test. Muscle contraction studies where carried out using the vascular reactivity on aortic smooth muscle. The oils exhibited concentration dependent anti-asthma and anti-cough activities. Significantly, 1,8-cineole isolated and purified from the essential oil showed a concentration dependent anti-inflammatory, anti-cough and anti-asthma activity and The essential oils showed vasorelaxant activity. The ability of the essential oils and 1,8-cineole to directly dilate smooth muscle and relieve the stress of bronchial contraction and obstruction of the airways passage validates the use of Eucalyptus grandis as an anti-asthmatic and anti-cough agent. It is concluded that the essential oils have the potential to be used as an anti-asthma and anti-cough therapy. This study also justifies its use by traditional healers in the treatment of asthma and coughs in Zulu folklore medicine.

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