Protective role of aqueous extract of Phyllanthus amarus on oxidative stress in pancreas of streptozotocin induced diabetic male Wistar rats

How to Cite

Bongu, S. B. R., Sagree, S., Gudapareddy, V., Putakala, M., Nukala, S., Gujjala, S., Bellamkonda, R., & Desireddy, S. (2016). Protective role of aqueous extract of Phyllanthus amarus on oxidative stress in pancreas of streptozotocin induced diabetic male Wistar rats. Journal of Experimental and Applied Animal Sciences, 2(1), 23–30. https://doi.org/10.20454/jeaas.2016.1087

Abstract

Diabetes mellitus has been associated with oxidative stress. The present study was performed to investigate the pancreas protective activities of Phyllanthus amarus aqueous extract (PAAEt) in streptozotocin (STZ) induced diabetic rats. Oral administration of PAAEt (200mg/kg bw) to diabetic rats for 60 days significantly (p<0.05) decreased antioxidant enzymes such as glutathione peroxidase, glutathione-s-transferase, glutathione reductase, superoxide dismutase, catalase and depletion of reduced glutathione in panceas which illustrates that increased lipid peroxidation (107 %) was restored to control levels. Co-treatment with PAAEt revealed the therapeutic efficacy against oxidative stress in pancreatic tissue. Hence extract of this plant could be used as an adjuvant therapy for the prevention and/or management of diabetes.
https://doi.org/10.20454/jeaas.2016.1087

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