Evaluation of anticonvulsant potential of aqueous methanolic extract and various fractions of Ajuga bracteosa wall
PDF

How to Cite

Qasim, S., Uttra, A. M., Hasan, U. H., & Batool, A. (2017). Evaluation of anticonvulsant potential of aqueous methanolic extract and various fractions of Ajuga bracteosa wall. Journal of Experimental and Applied Animal Sciences, 2(2), 137–146. https://doi.org/10.20454/jeaas.2017.1254

Abstract

We aim to assess the anticonvulsant potential of Ajuga bracteosa Wall. The aqueous methanol extract (30:70) of Ajuga bracteosa and its n-hexane, chloroform and ethyl acetate fractions were prepared. Anticonvulsant effect was evaluated using different animal models of epilepsy. Crude extract along with its fractions at 500 and 1000 mg/kg doses, administered orally to albino mice were appraised against pentylenetetrazole-induced, strychnine-induced and picrotoxin-induced convulsions. Moreover, effect of test substances on brain GABA level and phenobarbitone induced hypnosis was also studied at dose level of 350 and 400 mg/kg. The plant extract and its fractions produced potent dose dependent anticonvulsant activity in all models of epilepsy. In addition, plant extract and fractions increased brain GABA level and potentiated phenobarbitone-induced sleep duration. From the results it can be deduced that Ajuga bracteosa possess potent anticonvulsant activity, supporting its folkloric use in the treatment of epilepsy.

https://doi.org/10.20454/jeaas.2017.1254
PDF

Metrics

Metrics Loading ...