It is well known that production of ROS compounds and generation of oxidative stress duringÂ diabetes are the most important mechanisms of tissue damage. The aim of this study was toÂ examine the effects of atorvastatin treatment, as an antioxidant, to prevent the brain tissue oxidativeÂ stress in streptozotocin-induced diabetic rats. Male Wistar rats were randomly dividedÂ into four groups (five rats in each group) as followed: normal, normal treated was orally receivedÂ 20 mg/kg/day atorvastatin for 30 days, diabetic group was given 40 mg/kg streptozotocinÂ by intravenous injection and diabetic treated similar to normal treated rats. After 30 days ofÂ treatment, rats were sacrificed under deep anesthesia to remove the brain. After tissue homogenization,Â superoxide dismutase (SOD) and catalase (CAT) activities, as well as glutathioneÂ (GSH) and malondialdehyde (MDA) levels were determined by biochemical methods. In additionÂ to increase blood glucose level in diabetic rats (78%), brain SOD and CAT activities wereÂ significantly increased compared with normal rats. Also, diabetes significantly decreased theÂ GSH content of brain tissue by 57%, and increased the brain MDA level by 35%. FinallyÂ treatment with atorvastatin significantly decreased the augmented brain CAT activity and theÂ MDA level during diabetes. Based on the finding of this study, diabetes-induced hyperglycemiaÂ provoked the production of free radicals in the brain tissue that leading to oxidative stress.Â Also, treatment with atorvastatin may have prevented from hyperglycemia-induced oxidativeÂ stress in the brain of diabetic rat.