The aim of the present investigation was to evaluate the ameliorative effect of Eclipta albaÂ extract against carbon tetrachloride (CCl4)â€“induced structural and functional changes in liversÂ of mice. Healthy adult Swiss strain female albino mice were orally administered withÂ CCl4 (826 mg/kg body weight/day, p.o.) alone and along with Eclipta alba extract (100, 200Â and 300 mg/kg body weight/day, p.o.) for 30 days. The degree of protection was determinedÂ by measuring histopathological changes and lipid peroxidation in liver as well as activities ofÂ ALT, AST, ACP, ALP, LDH, Î³-GT enzymes and bilirubin contents in serum of mice. TheÂ histopathological studies revealed severe necrosis, fatty infiltration, lymphocytic infiltrationÂ and fibrosis in liver of CCl4 treated mice. In addition, biochemical studies revealed a significantÂ increase in lipid peroxidation. The enzymes activities as well as bilirubin contents in serumÂ were significantly (p<0.05) increased in CCl4 only treated mice when compared withÂ the control group. However, co-treatment of CCl4 along with Eclipta alba extract showedÂ significant reductions in activities of enzymes and bilirubin content as compared with CCl4Â alone treated mice. The effects were dose-dependent (r = 0.9826 to 1). Carbon tetrachlorideÂ induced lipid peroxidation was significantly (p<0.05) ameliorated in a dose-dependent manner.Â Histopathological changes were also ameliorated on treatment with Eclipta alba extract.Â The ameliorative effects of Eclipta alba on CCl4â€“induced hepatotoxicity could be due to itsÂ antioxidative property. The extract was found to be safe as evidenced by their high LD50.