Noninvasive motor evoked potentials with surface stimulation in rodents
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Graham, W. A., Kwiecien, J. M., & Nesathurai, S. (2014). Noninvasive motor evoked potentials with surface stimulation in rodents. Journal of Experimental and Applied Animal Sciences, 1(2), 182–185. https://doi.org/10.20454/jeaas.2014.793

Abstract

Motor evoked potentials are used routinely in clinical practice to assess the integrity of the spinal cord during surgery, and in evaluation of many diseases. Motor evoked potentials (MEPs) can be obtained by stimulation of the brain with recording over a skeletal muscle or peripheral nerve. In rats, motor evoked potentials have been used in animal models of a number of spinal cord injury and motor neuron disease. These studies are typically performed with stimulation via implanted electrodes. We are unaware of reports of MEPs being obtained with surface stimulation of the brain. In this study, MEPs were obtained on Long Evans rats using surface stimulation. Motor evoked potentials were consistently elicited in a group of 10 Long Evans (LE) rats. The mean onset latency and amplitude were 5.6 ± 0.4 and 1.9 ± 0.5. In conclusion, it is possible to record motor evoked potentials with surface stimulation and recording in rodents.

https://doi.org/10.20454/jeaas.2014.793
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