AbstractAnti-ulcer activity was evaluated with ethyl acetate and chloroform fractions of ethanolic extract of Maytenus emarginata Willd. Using an aspirin induced pylorus ligation model in rats as acute study for 4 days.
Wistar albino rats either male or female were divided into six groups (Standard, control and 4 groups for two different doses 125 and 200 mg/kg body weight of ethyl acetate and chloroform fractions), each group consisting of six animals. The parameters taken to assess antiulcer activity were volume of gastric secretion, pH, free acidity, total acidity and ulcer index. The results indicate thatÂ the ethyl acetate fraction of ethanolic extract significantly (P < 0.05) increases pH andÂ decreases the volume of gastric acid secretion, free acidity, total acidity and ulcer index with respect to control at a dose of 200 mg/kg body weight.
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